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. 2017 Apr;36(4):401-404.
doi: 10.1097/INF.0000000000001491.

Response to Tenofovir Among Lamivudine-experienced Hepatitis B and HIV-coinfected Adolescents

Linda Aurpibul  1 , Pagakrong Lumbiganon, Rawiwan Hansudewechakul, Suparat Kanjanavanit, Torsak Bunupuradah, Pope Kosalaraksa, Pawinee Taeprasert, Thanyawee Puthanakit
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Response to Tenofovir Among Lamivudine-experienced Hepatitis B and HIV-coinfected Adolescents

Linda Aurpibul et al. Pediatr Infect Dis J. 2017 Apr.

Abstract

We determined hepatitis B virus (HBV) suppression rates among 18 lamivudine (3TC)-experienced HBV-human immunodeficiency virus-coinfected adolescents after treatment with tenofovir disoproxil fumurate (TDF). At TDF initiation, their median age was 17.6 years, and duration of 3TC exposure was 7.3 years. Eleven patients (61%) achieved HBV DNA <60 IU/mL after 48 weeks on TDF and 3TC which was similar to adult studies, although hepatitis B surface antigen loss or hepatitis B envelope antigen seroconversion did not occur.

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Figures

Figure 1
Figure 1
Figure 1a Percentage of patients with detectable HBV DNA at baseline who had HBV suppression overtime Figure 1b HBV DNA level of 16 patients at each time point of study (log10IU/mL) Figure 1c Change in Alanine aminotransferase (ALT) in relation to HBV DNA level overtime in 3 patients with increase ALT at baseline
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