Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Dec 22;11(12):e0168598.
doi: 10.1371/journal.pone.0168598. eCollection 2016.

Prediction of Coronary Artery Disease Extent and Severity Using Pulse Wave Velocity

Joseph Chiha  1 , Paul Mitchell  2 , Bamini Gopinath  2 , George Burlutsky  2 , Adam Plant  2 , Pramesh Kovoor  1 , Aravinda Thiagalingam  1
Affiliations

Prediction of Coronary Artery Disease Extent and Severity Using Pulse Wave Velocity

Joseph Chiha et al. PLoS One. .

Abstract

Background: Pulse-wave velocity (PWV) measures aortic stiffness. It is an independent predictor of cardiovascular events and mortality, yet there is paucity in the literature on its association with the severity and extent of coronary artery disease (CAD).

Methods: To examine the utility of PWV in predicting CAD burden in men and women the PWV was determined in 344 patients (Men = 266, Women = 78) presenting for invasive coronary angiography for the assessment of suspected CAD. Pearson correlations and multivariate analysis were used to evaluate the relationship between these coronary scores, PWV and traditional cardiovascular risk factors.

Results: Compared to men, women with chest pain had lower mean Extent scores (19.2 vs. 35.6; p = 0.0001) and Gensini scores (23.6 vs. 41.9; p = 0.0001). PWV was similar between men and women (12.35 ± 3.74 vs. 12.43 ± 4.58; p = 0.88) and correlated with Extent score (r = 0.21, p = 0.0001) but not Gensini or vessel score (r = 0.03, p = 0.64 and r = 0.06, p = 0.26, respectively). PWV was associated with Extent score in men (B = 2.25 ± 0.78, p = 0.004 for men and B = 1.50 ± 0.88, p = 0.09 for women). It was not a predictor of Gensini score (B = -0.10, P = 0.90).

Conclusion: PWV correlates with the extent of CAD, as measured by the 'Extent' score in men more than women. However, it does not correlate with the severity of obstructive CAD in either gender.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The relationship of pulse-wave velocity (PWV) with Extent and Gensini score in men (A) and women (B) using a univariate linear regression analysis.
Caption: Solid line = regression line, dotted line = 95% confidence interval. The Δβ represents the change in value of the Extent or Gensini score with every 1 m/s increase in the PWV result. Significant dependent correlations have p < 0.05. PWV, pulse-wave velocity.
See this image and copyright information in PMC

References

    1. Sharaf BL, Pepine CJ, Kerensky RA, Reis SE, Reichek N, Rogers WJ, et al. Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory). Am J Cardiol. 2001;87(8):937–41; A3 Epub 2001/04/18. - PubMed
    1. Kemp HG, Kronmal RA, Vlietstra RE, Frye RL. Seven year survival of patients with normal or near normal coronary arteriograms: a CASS registry study. J Am Coll Cardiol. 1986;7(3):479–83. Epub 1986/03/01. - PubMed
    1. Jespersen L, Hvelplund A, Abildstrom SZ, Pedersen F, Galatius S, Madsen JK, et al. Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events. Eur Heart J. 2012;33(6):734–44. Epub 2011/09/14. 10.1093/eurheartj/ehr331 - DOI - PubMed
    1. Patel MR, Peterson ED, Dai D, Brennan JM, Redberg RF, Anderson HV, et al. Low diagnostic yield of elective coronary angiography. N Engl J Med. 2010;362(10):886–95. Epub 2010/03/12. 10.1056/NEJMoa0907272 - DOI - PMC - PubMed
    1. Lamendola P, Lanza GA, Spinelli A, Sgueglia GA, Di Monaco A, Barone L, et al. Long-term prognosis of patients with cardiac syndrome X. Int J Cardiol. 2010;140(2):197–9. 10.1016/j.ijcard.2008.11.026 - DOI - PubMed