Comment
doi: 10.1126/science.aaf6236.
Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2"
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- PMID: 28008037
- DOI: 10.1126/science.aaf6236
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Comment
Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2"
Science.
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Abstract
Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.
Copyright © 2016, American Association for the Advancement of Science.
Comment in
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Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".Science. 2016 Dec 23;354(6319):1543. doi: 10.1126/science.aaj2335. Science. 2016. PMID: 28008038 Free PMC article.
Comment on
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Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2.Science. 2015 Oct 16;350(6258):aac4383. doi: 10.1126/science.aac4383. Epub 2015 Oct 15. Science. 2015. PMID: 26472914 Free PMC article.
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