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Comment
. 2016 Dec 23;354(6319):1543.
doi: 10.1126/science.aaf6236.

Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2"

Ying Zhang  1 , Neil Justin  1 , Jon R Wilson  1 , Steven J Gamblin  2
Affiliations
Comment

Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2"

Ying Zhang et al. Science. .

Abstract

Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.

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