Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Jan;440(Suppl 1):R168-R170.
doi: 10.1007/s004240000050.

The development of the method for the determination of terbinafine in cat's plasma and hair

Nevenka Kožuh Eržen  1 , Jernej Kužner  1 , Marinka Drobnič-Košorok  1
Affiliations

The development of the method for the determination of terbinafine in cat's plasma and hair

Nevenka Kožuh Eržen et al. Pflugers Arch. 2000 Jan.

Abstract

Clinical investigations of terbinafine indicate its high treatment activity against infections by several dermatophytes. Its efficiency was tested also in the treatment of microsporosis in cats. The distribution of terbinafine in cat's plasma and hair is important for the identification of the drug efficiency. A fast and reliable reversed-phase high performance liquid chromatographic method with appropriate sample preparation has been developed.Reliability, good reproducibility and low detection limit (LOD 0.25 ng/ml) of the method enable determination of terbinafine in hair and also in plasma of cats infected with Microsporum canis treated by Lamisil® tablets.

Keywords: HPLC method; Key words: microsporosis; cats; terbinafine.

PubMed Disclaimer

LinkOut - more resources