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Comment
. 2017 Jun;83(6):1350-1352.
doi: 10.1111/bcp.13188. Epub 2016 Dec 22.

Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance

Elisabet Størset  1   2 , Kristine Hole  3 , Karsten Midtvedt  1 , Stein Bergan  4   5 , Espen Molden  3   4 , Anders Åsberg  1   4
Affiliations
Comment

Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance

Elisabet Størset et al. Br J Clin Pharmacol. 2017 Jun.
No abstract available

Keywords: 4β-hydroxycholesterol; CYP3A; bodyweight; kidney transplantation; tacrolimus.

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Figures

Figure 1
Figure 1
Data from 43 renal transplant recipients at our center illustrate how a significant correlation is introduced between 4β‐hydroxycholesterol (4βOHC) and tacrolimus (Tac) apparent clearance (CL/F) by dividing both variables on bodyweight. (A) 4βOHC vs. Tac CL/F, (B) Weight vs. Tac CL/F, (C) Weight vs. 4βOHC, (D) Weight vs. weight‐adjusted (/W) Tac CL/F, (E) Weight vs. weight‐adjusted 4βOHC, (F) Weight‐adjusted 4βOHC vs. weight‐adjusted Tac CL/F
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