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. 2017 Feb;29(7).
doi: 10.1002/adma.201603239. Epub 2016 Dec 23.

Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy

Flavia Fontana  1 , Mohammad-Ali Shahbazi  1 , Dongfei Liu  1   2 , Hongbo Zhang  1   2 , Ermei Mäkilä  3 , Jarno Salonen  3 , Jouni T Hirvonen  1 , Hélder A Santos  1
Affiliations

Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy

Flavia Fontana et al. Adv Mater. 2017 Feb.

Abstract

Immunoadjuvant porous silicon (PSi)-based nanovaccines are prepared by nanoprecipitation in a glass capillary microfluidics device. Vesicles, derived from cancer cell membranes encapsulating thermally oxidized PSi nanoparticles or PSi-polymer nanosystems binding a model antigen, are biocompatible over a wide range of concentrations, and show immunostimulant properties in human cells, promoting the expression of co-stimulatory signals and the secretion of pro-inflammatory cytokines.

Keywords: acetalated dextran; cancer cell membranes; cancer immunotherapy; nanovaccines; porous silicon.

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