Reply

Gordon D McLaren^{1

2}, James C Barton³, Grant A Ramm^{4

5}, Mary J Emond⁶, V Nathan Subramaniam^{4

7}, Pradyumna D Phatak⁸, Paul C Adams⁹, Lawrie W Powell^{4

5

10}, Lyle C Gurrin¹¹, Gregory J Anderson^{4

12}, Christine E McLaren¹³

Affiliations

¹ Department of Veterans Affairs Long Beach Healthcare System, Long Beach, CA.
² Division of Hematology/Oncology Department of Medicine, University of California, Irvine, CA.
³ Southern Iron Disorders Center, Birmingham, AL.
⁴ QIMR Berghofer Medical Research Institute, Brisbane, Australia.
⁵ Faculty of Medicine and Biomedical Sciences, University of Queensland, Brisbane, Australia.
⁶ Department of Biostatistics, University of Washington, Seattle, WA.
⁷ Institute of Health and Biomedical Innovation School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
⁸ Rochester General Hospital, Rochester, NY.
⁹ Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.
¹⁰ Royal Brisbane & Women's Hospital, Brisbane, Australia.
¹¹ Centre for MEGA Epidemiology, University of Melbourne, Melbourne, Australia.
¹² School of Medicine and School of Chemistry and Molecular Bioscience, University of Queensland, Brisbane, Australia.
¹³ Department of Epidemiology, University of California, Irvine, CA.

Comment

Gordon D McLaren et al. Hepatology. 2017 Mar.

. 2017 Mar;65(3):1072-1073.

doi: 10.1002/hep.29002. Epub 2017 Feb 3.

¹ Department of Veterans Affairs Long Beach Healthcare System, Long Beach, CA.
² Division of Hematology/Oncology Department of Medicine, University of California, Irvine, CA.
³ Southern Iron Disorders Center, Birmingham, AL.
⁴ QIMR Berghofer Medical Research Institute, Brisbane, Australia.
⁵ Faculty of Medicine and Biomedical Sciences, University of Queensland, Brisbane, Australia.
⁶ Department of Biostatistics, University of Washington, Seattle, WA.
⁷ Institute of Health and Biomedical Innovation School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
⁸ Rochester General Hospital, Rochester, NY.
⁹ Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.
¹⁰ Royal Brisbane & Women's Hospital, Brisbane, Australia.
¹¹ Centre for MEGA Epidemiology, University of Melbourne, Melbourne, Australia.
¹² School of Medicine and School of Chemistry and Molecular Bioscience, University of Queensland, Brisbane, Australia.
¹³ Department of Epidemiology, University of California, Irvine, CA.

Erratum in

Correction.
[No authors listed] [No authors listed] Hepatology. 2017 Jun;65(6):2136. doi: 10.1002/hep.29205. Epub 2017 May 3. Hepatology. 2017. PMID: 28543161 No abstract available.

No abstract available

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.
McLaren CE, Emond MJ, Subramaniam VN, Phatak PD, Barton JC, Adams PC, Goh JB, McDonald CJ, Powell LW, Gurrin LC, Allen KJ, Nickerson DA, Louie T, Ramm GA, Anderson GJ, McLaren GD. McLaren CE, et al. Hepatology. 2015 Aug;62(2):429-39. doi: 10.1002/hep.27711. Epub 2015 Mar 18. Hepatology. 2015. PMID: 25605615 Free PMC article.
GNPAT polymorphism rs11558492 is not associated with increased severity in a large cohort of HFE p.Cys282Tyr homozygous patients.
Tchernitchko D, Scotet V, Lefebvre T, L'Hostis C, Gourlaouen I, Merour MC, Rebah K, Peoc'h K, Assari S, Ferec C, Puy H, Le Gac G. Tchernitchko D, et al. Hepatology. 2017 Mar;65(3):1069-1071. doi: 10.1002/hep.28742. Epub 2016 Oct 6. Hepatology. 2017. PMID: 27474861 No abstract available.

1. McLaren CE, Emond MJ, Subramaniam VH, Phatak PD, Barton JC, Adams PC, et al. Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology. 2015;62:429–439. - PMC - PubMed
1. Besson-Fournier C, Martinez M, Vinel JP, Aguilar-Martinez P, Coppin H, Roth MP. Further support for the association of GNPAT variant rs11558492 with severe iron overload in hemochromatosis. Hepatology. 2016;63(6):2054–5. - PubMed
1. Hsiao SC, Lee CT, Pei SN. GNPAT variant is associated with iron phenotype in healthy Taiwanese women: A population without the HFE C282Y mutation. Hepatology. 2016;63(6):404–11. - PubMed