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Review
. 2017 Jan:109:69-78.
doi: 10.1016/j.critrevonc.2016.11.017. Epub 2016 Dec 1.

Emergence of miR-34a in radiation therapy

Jerome Lacombe  1 , Frederic Zenhausern  2
Affiliations
Review

Emergence of miR-34a in radiation therapy

Jerome Lacombe et al. Crit Rev Oncol Hematol. 2017 Jan.

Abstract

Expressions of many microRNAs (miRNAs) in response to ionizing radiation (IR) have already been investigated and some of them seem to play an important role in the tumor radioresistance, normal tissue radiotoxicity or as predictive biomarkers to radiation. miR-34a is an emerging miRNA in recent radiobiology studies. Here, we review this miR-34 family member by detailing its different roles in radiation response and we will discuss about the role that it can play in radiation treatment. Thus, we will show that IR regulates miR-34a by increasing its expression. We will also highlight different biological processes involved in cellular response to IR and regulated by miR-34a in order to demonstrate the role it can play in tumor radio-response or normal tissue radiotoxicity as a radiosensitizer or radioprotector. miR-34a is poised to assert itself as an important player in radiobiology and should become more and more important in radiation therapy management.

Keywords: Biodosimetry; Biomarkers; Ionizing radiation; Oncology; Radiotherapy; Radiotoxicity; miR-34a.

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Conflict of interest statement

statement None

Figures

Figure 1
Figure 1
miR-34a targets which enhance tumor radiosensitivity. DSB: double-strand break
Figure 2
Figure 2
Biological processes regulated by miR-34a which might be involved in normal tissue radiation-induced toxicity
Figure 3
Figure 3
main miR-34a targets. MiR-34a downregulates many genes by binding their three prime untranslated region (red). MiR-34a is also known as an activator of the major p53 pathway (green).
See this image and copyright information in PMC

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