Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jan:109:9-19.
doi: 10.1016/j.critrevonc.2016.11.007. Epub 2016 Nov 23.

Clinical relevance of colorectal cancer molecular subtypes

Nuria Rodriguez-Salas  1 , Gema Dominguez  2 , Rodrigo Barderas  3 , Marta Mendiola  4 , Xabier García-Albéniz  5 , Juan Maurel  6 , Jaime Feliu Batlle  7
Affiliations
Review

Clinical relevance of colorectal cancer molecular subtypes

Nuria Rodriguez-Salas et al. Crit Rev Oncol Hematol. 2017 Jan.

Abstract

Colorectal cancer (CRC) is characterized by alteration of critical pathways such TP53 inactivation, BRAF, PI3CA mutations, APC inactivation, KRAS, TGF-β, CTNNB mutations, disregulation of Epithelial to mesnechymal transition (EMT) genes, WNT signaling activation, MYC amplification, and others. Differences in these molecular events results in differences in phenotypic characteristics of CRC, that have been studied and classified by different models of molecular subtypes. It could have potential applications to prognosis, but also to therapeutical approaches of the CRC patients. We review and summarized the different molecular classifications and try to clarify their clinical and therapeutical relevance.

Keywords: Colorectal cancer; Molecular subtypes; Personalized treatment.

PubMed Disclaimer