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. 2017 Feb 1;27(3):557-561.
doi: 10.1016/j.bmcl.2016.12.020. Epub 2016 Dec 8.

Triterpene saponins and megastigmane glucosides from Camellia bugiamapensis

Nguyen Thi Huong  1 , Le Thi Vien  1 , Tran Thi Hong Hanh  1 , Nguyen Hai Dang  1 , Nguyen Van Thanh  1 , Nguyen Xuan Cuong  1 , Nguyen Hoai Nam  2 , Luu Hong Truong  3 , Ninh Khac Ban  1 , Phan Van Kiem  1 , Chau Van Minh  4
Affiliations

Triterpene saponins and megastigmane glucosides from Camellia bugiamapensis

Nguyen Thi Huong et al. Bioorg Med Chem Lett. .

Abstract

Two new triterpene saponins, camelliosides I and J (1 and 2), two new megastigmane glycosides, camellistigosides A and B (3 and 4), and two known megastigmane glycosides, icariside B1 (5) and (6S,9R)-roseoside (6), were isolated from a methanol extract of the Camellia bugiamapensis leaves using various chromatographic separation techniques. Their structures were elucidated based on spectroscopic analyses, including HR ESI MS, CD, 1D and 2D NMR. Their inhibitory effects on LPS-induced NO production in RAW264.7 cells were evaluated. This is the first report of the chemical constituents and biological activity of C. bugiamapensis.

Keywords: Camellia bugiamapensis; NO production; Theaceae.

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