Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Feb;65(2):404-406.
doi: 10.1002/hep.28925. Epub 2016 Dec 24.

Extracellular vesicles as therapeutic carriers of microRNAs for cholangiocarcinoma

Sergio A Gradilone  1
Affiliations
Editorial

Extracellular vesicles as therapeutic carriers of microRNAs for cholangiocarcinoma

Sergio A Gradilone. Hepatology. 2017 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Potential conflict of interest: Nothing to report.

Figures

FIG. 1
FIG. 1
Mutual regulation between tumor and stromal cells. Coculture of CCA and stellate cell lines induces the down-regulation of specific miRNAs in the stromal cells, including miR-195. In turn, stellate cells secrete EVs (exosomes derived from the multivesicular bodies [MVB] and microvesicles originated by direct budding from the plasma membrane). Experimental overloading of EVs with miR-195 specifically targeted tumor cells and discharged their content inside the cytoplasm, regulating several growth factors and cell cycle–related proteins and resulting in inhibited proliferation.
See this image and copyright information in PMC

Comment on

References

    1. Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, et al. Expert consensus document: cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) Nat Rev Gastroenterol Hepatol. 2016;13:261–280. - PubMed
    1. Li L, Piontek K, Ishida M, Fausther M, Dranoff JA, Fu R, et al. Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model. HEPATOLOGY. 2017;65:501–514. - PMC - PubMed
    1. Sato K, Meng F, Glaser S, Alpini G. Exosomes in liver pathology. J Hepatol. 2016;65:213–221. - PMC - PubMed
    1. Desrochers LM, Antonyak MA, Cerione RA. Extracellular vesicles: satellites of information transfer in cancer and stem cell biology. Dev Cell. 2016;37:301–309. - PMC - PubMed
    1. Dutta S, Reamtong O, Panvongsa W, Kitdumrongthum S, Janpipatkul K, Sangvanich P, et al. Proteomics profiling of cholangiocarcinoma exosomes: a potential role of oncogenic protein transferring in cancer progression. Biochim Biophys Acta. 2015;1852:1989–1999. - PubMed