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. 2017 Mar-Apr:42:147-151.
doi: 10.1016/j.clinimag.2016.11.015. Epub 2016 Nov 30.

Radiogenomic evaluation of lung cancer - Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations?

Darragh F Halpenny  1 , Andrew Plodkowski  2 , Gregory Riely  3 , Junting Zheng  4 , Anya Litvak  3 , Chaya Moscowitz  4 , Michelle S Ginsberg  2
Affiliations

Radiogenomic evaluation of lung cancer - Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations?

Darragh F Halpenny et al. Clin Imaging. 2017 Mar-Apr.

Abstract

Introduction: We studied computed tomography (CT) features associated with BRAF mutated lung cancer.

Materials and methods: CT features of BRAF mutated lung cancers were compared to stage matched lesions without BRAF mutation.

Results: 47 (25%) patients with BRAF mutation and 141 (75%) without BRAF mutation were included. BRAF lesions were most frequently solid 37 (84%), spiculated 22 (50%), and peripheral 37 (84%). No feature of the primary tumor was significantly different between BRAF and non-BRAF groups. BRAF patients were more likely than KRAS patients to have pleural metastases [5 (11%) vs 0 (0%), p=0.045].

Conclusion: No feature of the primary tumor differentiates BRAF lesions from non-BRAF lesions.

Keywords: BRAF mutation; Computed tomography; Lung carcinoma; Radiogenomics.

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Figures

Figure 1
Figure 1
Chest CT on lung windows demonstrating a primary lung tumor (arrow) in the right upper lobe, in a patient with BRAF mutated lung cancer. The lesion is peripherally based, solid and spiculated, the most common imaging phenotype found in patients with a BRAF mutation. A loculated pleural effusion is also demonstrated (arrowheads), in this patient with pleural metastases (pleural metastases not visualized on this image).
See this image and copyright information in PMC

References

    1. Jemal A, Seigel R, Ward E, et al. Cancer statistics 2006. CA Cancer J Clin. 2006;56:106–130. - PubMed
    1. Shaw AT, Kim DW, Nakagawa K, Seto T, Crinó L, Ahn MJ, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013 Jun 20;368(25):2385–2394. - PubMed
    1. Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non– small-cell lung cancer to gefitinib. N Engl J Med. 2004;350:2129–2139. - PubMed
    1. Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417:949–954. - PubMed
    1. Paik PK, Arcila ME, Fara M, et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol. 2011;29:2046–2051. - PMC - PubMed

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