Review
doi: 10.1016/j.bcp.2016.12.015.
Epub 2016 Dec 22.
Non-coding RNAs as antibiotic targets
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- PMID: 28012959
- DOI: 10.1016/j.bcp.2016.12.015
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Review
Non-coding RNAs as antibiotic targets
Biochem Pharmacol.
.
Abstract
Antibiotics inhibit a wide range of essential processes in the bacterial cell, including replication, transcription, translation and cell wall synthesis. In many instances, these antibiotics exert their effects through association with non-coding RNAs. This review highlights many classical antibiotic targets (e.g. rRNAs and the ribosome), explores a number of emerging targets (e.g. tRNAs, RNase P, riboswitches and small RNAs), and discusses the future directions and challenges associated with non-coding RNAs as antibiotic targets.
Keywords: Antibiotic; Non-coding RNA; Ribosome; Riboswitch; tRNA.
Copyright © 2016 Elsevier Inc. All rights reserved.
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