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Review
. 2017 Jun 1:133:29-42.
doi: 10.1016/j.bcp.2016.12.015. Epub 2016 Dec 22.

Non-coding RNAs as antibiotic targets

Savannah Colameco  1 , Marie A Elliot  2
Affiliations
Review

Non-coding RNAs as antibiotic targets

Savannah Colameco et al. Biochem Pharmacol. .

Abstract

Antibiotics inhibit a wide range of essential processes in the bacterial cell, including replication, transcription, translation and cell wall synthesis. In many instances, these antibiotics exert their effects through association with non-coding RNAs. This review highlights many classical antibiotic targets (e.g. rRNAs and the ribosome), explores a number of emerging targets (e.g. tRNAs, RNase P, riboswitches and small RNAs), and discusses the future directions and challenges associated with non-coding RNAs as antibiotic targets.

Keywords: Antibiotic; Non-coding RNA; Ribosome; Riboswitch; tRNA.

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