Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Oct 1;56(10):1648-1661.
doi: 10.1093/rheumatology/kew418.

Assessment and management of musculoskeletal disorders among patients living with HIV

Karen Walker-Bone  1   2 , Erin Doherty  3 , Kaushik Sanyal  4 , Duncan Churchill  5
Affiliations
Review

Assessment and management of musculoskeletal disorders among patients living with HIV

Karen Walker-Bone et al. Rheumatology (Oxford). .

Abstract

HIV is a global pandemic. However, anti-retroviral therapy has transformed the prognosis and, providing compliance is good, a normal life expectancy can be anticipated. This has led to increasing numbers of people with chronic prevalent, treated infection living to older ages. Musculoskeletal pain is commonly reported by HIV patients and, with resumption of near-normal immune function, HIV-infected patients develop inflammatory rheumatic diseases that require assessment and management in rheumatology clinics. Moreover, it is becoming apparent that avascular necrosis and osteoporosis are common comorbidities of HIV. This review will contextualize the prevalence of musculoskeletal symptoms in HIV, informed by data from a UK-based clinic, and will discuss the management of active inflammatory rheumatic diseases among HIV-infected patients taking anti-retroviral therapy, highlighting known drug interactions.

Keywords: HIV; biologics; disease-modifying anti-rheumatic drugs; inflammatory rheumatic disease; musculoskeletal.

PubMed Disclaimer

Conflict of interest statement

Disclosure

None of the authors declare any conflict of interest in relation to this manuscript.

References

    1. UN Joint Programme on HIV/AIDS. Global Report: UN AIDS report on the global AIDS epidemic 2013. United Nations; Geneva: 2013. Nov, Available via: http://www.unaids.org/en/resources/campaigns/globalreport2013/globalreport/
    1. May MT, Vehreschild JJ, Trickey A, et al. Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment: Collaborative Cohort Study. Clin Infect Dis. 2016 Mar 29; pii: ciw183. [Epub ahead of print] - PMC - PubMed
    1. Lawson E, Sabin C, Perry N, et al. Is HIV painful? An epidemiologic study of the prevalence and risk factors for pain in HIV-infected patients. Clin J Pain. 2014 Oct 17; [Epub ahead of print] - PMC - PubMed
    1. Skingsley A, Kirwan P, Yin Z, et al. HIV new diagnoses treatment and care in the UK- Situation Report 2015: data to end 2014. Public Health England; London: 2015. Nov,
    1. Health Protection Agency. Time to test for HIV: Expanding HIV testing in healthcare and community services in England. Final report. 2011 www.bhiva.org/documents/Publications/Time_to_test_final_report__Sept_201....

MeSH terms

Substances