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Comparative Study
. 2017 Jul 1;58(4):552-558.
doi: 10.1093/jrr/rrw119.

Comparative effectiveness of radical prostatectomy and curative radiotherapy in localized prostate cancer: long-term follow-up

Satoshi Tamada  1 , Noriko Ninomiya  1 , Koichiro Kitamoto  1 , Minoru Kato  1 , Takeshi Yamasaki  1 , Taro Iguchi  1 , Tetsuji Ohmachi  2 , Tatsuya Nakatani  1
Affiliations
Comparative Study

Comparative effectiveness of radical prostatectomy and curative radiotherapy in localized prostate cancer: long-term follow-up

Satoshi Tamada et al. J Radiat Res. .

Abstract

We sought to investigate the long-term outcomes after radical prostatectomy (RP) and external-beam radiation therapy (EBRT) for the treatment of localized prostate cancer in Japanese patients. RP and radiation therapy are curative treatments for localized prostate cancer. However, there is controversy around which treatment is superior in Japanese patients. The aim of our retrospective study was to compare the long-term clinical outcomes of each treatment. We retrospectively evaluated the overall survival (OS), cancer-specific survival (CSS) and biochemical failure-free survival (BFS) for patients who had been diagnosed with localized prostate cancer and treated with RP (n = 248) or conventional 2D or 3D-CRT EBRT (n = 182) between 1995 and 2009. The median OS was superior in the RP group compared with that in EBRT group (P < 0.001), although CSS was comparable for both treatment groups; BFS was superior for the EBRT group compared with that for the RP group (P = 0.04). Univariate analysis identified a prostate-specific antigen count (PSA)of ≥20 vs <20 mg/ml, clinical T-stage of the tumor and Gleason score as predictors for CSS. However, multivariate analysis did not identify a factor for CSS. Subgroup analysis was also performed based on clinical T stage, PSA and Gleason score, but there was no difference in each subgroup between RP and EBRT. Both treatments provided satisfactory clinical outcomes in terms of disease control in localized prostate cancer.

Keywords: external-beam radiation therapy; localized prostate cancer; overall survival; radical prostatectomy; retrospective study.

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Figures

Fig. 1.
Fig. 1.
The overall survival curves in the radical prostatectomy (RP) and external-beam radiation therapy (EBRT) groups.
Fig. 2.
Fig. 2.
The cause-specific survival curves in the radical prostatectomy (RP) and external-beam radiation therapy (EBRT) groups.
Fig. 3.
Fig. 3.
The biochemical disease-free survival curves in the radical prostatectomy (RP) and external-beam radiation therapy (EBRT) groups.
See this image and copyright information in PMC

References

    1. Matsuda A, Matsuda T, Shibata A, et al. . Cancer incidence and incidence rates in Japan in 2008: a study of 25 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project. Jpn J Clin Oncol 2014;44:388–96. - PubMed
    1. Penson DF. An update on randomized clinical trials in localized and locoregional prostate cancer. Urol Oncol 2005;23:280–8. - PubMed
    1. Paulson DF, Lin GH, Hinshaw W, et al. . Radical surgery versus radiotherapy for adenocarcinoma of the prostate. J Urol 1982;128:502–4. - PubMed
    1. Akakura K, Suzuki H, Ichikawa T, et al. . A randomized trial comparing radical prostatectomy plus endocrine therapy versus external beam radiotherapy plus endocrine therapy for locally advanced prostate cancer: results at median follow-up of 102 months. Jpn J Clin Oncol 2006;36:789–93. - PubMed
    1. Sooriakumaran P, Nyberg T, Akre O, et al. . Comparative effectiveness of radical prostatectomy and radiotherapy in prostate cancer: observational study of mortality outcomes. BMJ 2014;348:g1502. - PMC - PubMed

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