Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Feb;19(Suppl 1):74-94.
doi: 10.1007/s11121-016-0737-1.

Two-Year Impact of Prevention Programs on Adolescent Depression: an Integrative Data Analysis Approach

C Hendricks Brown  1 , Ahnalee Brincks  2   3 , Shi Huang  4 , Tatiana Perrino  3 , Gracelyn Cruden  5   6 , Hilda Pantin  3 , George Howe  7 , Jami F Young  8 , William Beardslee  9 , Samantha Montag  5 , Irwin Sandler  10
Affiliations

Two-Year Impact of Prevention Programs on Adolescent Depression: an Integrative Data Analysis Approach

C Hendricks Brown et al. Prev Sci. 2018 Feb.

Abstract

This paper presents the first findings of an integrative data analysis of individual-level data from 19 adolescent depression prevention trials (n = 5210) involving nine distinct interventions across 2 years post-randomization. In separate papers, several interventions have been found to decrease the risk of depressive disorders or elevated depressive/internalizing symptoms among youth. One type of intervention specifically targets youth without a depressive disorder who are at risk due to elevated depressive symptoms and/or having a parent with a depressive disorder. A second type of intervention targets two broad domains: prevention of problem behaviors, which we define as drug use/abuse, sexual risk behaviors, conduct disorder, or other externalizing problems, and general mental health. Most of these latter interventions improve parenting or family factors. We examined the shared and unique effects of these interventions by level of baseline youth depressive symptoms, sociodemographic characteristics of the youth (age, sex, parent education, and family income), type of intervention, and mode of intervention delivery to the youth, parent(s), or both. We harmonized eight different measures of depression utilized across these trials and used growth models to evaluate intervention impact over 2 years. We found a significant overall effect of these interventions on reducing depressive symptoms over 2 years and a stronger impact among those interventions that targeted depression specifically rather than problem behaviors or general mental health, especially when baseline symptoms were high. Implications for improving population-level impact are discussed.

Keywords: Cognitive behavioral therapy; Data synthesis; Growth mixture modeling; Growth modeling; Interpersonal therapy; Parenting interventions; Person-level meta-analysis.

PubMed Disclaimer

Figures

Figure 1a
Figure 1a
PRISMA Statement
Figure 2
Figure 2
Follow-Up Rates Across Time Footnote: Trial 18 is missing 49 participants at baseline.
Figure 3
Figure 3
Functional Transformation of Time Used in Growth Modeling
Figure 4
Figure 4
Depressive Symptoms across Time among Youth with High Symptoms at Baseline in Depression-Focused Trials and Among Youth with Low Symptoms at Baseline
Figure 5
Figure 5
Distribution of Intervention Versus Control Effect from 24 Interventions in 19 Trials
See this image and copyright information in PMC

References

    1. Achenbach TM. Manual for the Child Behavior Checklist/4-18 and 1991 Profile. University of Vermont Department of Psychiatry; Burlington, VT: 1991.
    1. Achenbach TM, Rescorla L. The Manual for the ASEBA school-age forms & profiles. University of Vermont, Research Center for Children, Youth, and Families; Burlington: 2001.
    1. Andrews G, Sanderson K, Corry J, Lapsley HM. Using epidemiological data to model efficiency in reducing the burden of depression. The journal of mental health policy and economics. 2000;3(4):175–186. - PubMed
    1. Asarnow JR, Jaycox LH, Duan N, LaBorde AP, Rea MM, Murray P, Wells KB. Effectiveness of a quality improvement intervention for adolescent depression in primary care clinics: a randomized controlled trial. Jama. 2005;293(3):311–319. doi:10.1001/jama.293.3.311. - PubMed
    1. Avenevoli S, Swendsen J, He J-P, Burstein M, Merikangas KR. Major Depression in the National Comorbidity Survey–Adolescent Supplement: Prevalence, Correlates, and Treatment. Journal of the American Academy of Child & Adolescent Psychiatry. 2015;54(1):37–44. e32. doi:10.1016/j.jaac.2014.10.010. - PMC - PubMed

Publication types

LinkOut - more resources