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. 2017 Jan;51(1):99-102.
doi: 10.4132/jptm.2016.09.30. Epub 2016 Dec 24.

Human Herpes Virus 8/Epstein-Barr Virus-Copositive, Plasmablastic Microlymphoma Arising in Multicentric Castleman's Disease of an Immunocompetent Patient

Yong-Moon Lee  1 , Jin-Man Kim  1 , Sam-Yong Kim  2
Affiliations

Human Herpes Virus 8/Epstein-Barr Virus-Copositive, Plasmablastic Microlymphoma Arising in Multicentric Castleman's Disease of an Immunocompetent Patient

Yong-Moon Lee et al. J Pathol Transl Med. 2017 Jan.
No abstract available

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Imaging and macroscopic findings of the lymph node. (A) Abdominal computed tomography showing multiple enlarged retroperitoneal lymph nodes along the axis. (B) A 5.0-cm round and tan to pinkish contexture demonstrated with vague lobulation on cut section.
Fig. 2.
Fig. 2.
Microscopic findings of the lymph node. (A) Low-magnification showing multiple, well-formed germinal centers. (B) The hyalinized vascular proliferations surrounding follicles characteristic of Castleman’s disease. (C) The confluent aggregates of plasmablasts in the germinal centers indicating the germinotrophism. (D) High-magnification showing the invasion of plasmablasts to the interfollicular spaces with sinusoidal pattern.
Fig. 3.
Fig. 3.
Immunohistochemical staining results of the lymph node. (A) MUM-1/IRF4-stain highlighting sheets of germinotrophic plasmablasts. (B) Epithelial membrane antigen–stain demonstrating confluent aggregation of plasmablasts with sinusoidal pattern. (C) Human herpes virus 8 encoded latency associated nuclear antigen 1 highlighting the atypical plasmablasts. (D) In situ hybridization for Epstein-Barr virus (EBV) encoded ribonucleic acids showing coinfection of EBV in the atypical plasmablasts.
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