Review
doi: 10.2174/1566524016666161223104915.
Sumoylation in Cellular Senescence and Aging
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- PMID: 28017139
- DOI: 10.2174/1566524016666161223104915
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Review
Sumoylation in Cellular Senescence and Aging
Curr Mol Med.
2017.
Abstract
Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.
Keywords: RB; Sumoylation; aging; p53; senescence.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
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