Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Oct:39:59-67.
doi: 10.1016/j.arr.2016.12.006. Epub 2016 Dec 23.

Circadian rhythms, time-restricted feeding, and healthy aging

Emily N C Manoogian  1 , Satchidananda Panda  2
Affiliations
Review

Circadian rhythms, time-restricted feeding, and healthy aging

Emily N C Manoogian et al. Ageing Res Rev. 2017 Oct.

Abstract

Circadian rhythms optimize physiology and health by temporally coordinating cellular function, tissue function, and behavior. These endogenous rhythms dampen with age and thus compromise temporal coordination. Feeding-fasting patterns are an external cue that profoundly influence the robustness of daily biological rhythms. Erratic eating patterns can disrupt the temporal coordination of metabolism and physiology leading to chronic diseases that are also characteristic of aging. However, sustaining a robust feeding-fasting cycle, even without altering nutrition quality or quantity, can prevent or reverse these chronic diseases in experimental models. In humans, epidemiological studies have shown erratic eating patterns increase the risk of disease, whereas sustained feeding-fasting cycles, or prolonged overnight fasting, is correlated with protection from breast cancer. Therefore, optimizing the timing of external cues with defined eating patterns can sustain a robust circadian clock, which may prevent disease and improve prognosis.

Keywords: Aging; Circadian rhythms; Health; Metabolism; Time-restricted feeding.

PubMed Disclaimer

References

    1. Akram M. A Focused Review of the Role of Ketone Bodies in Health and Disease. J. Med. Food. 2013;0:1–3. - PubMed
    1. Ancoli-Israel S, Gehrman P, Martin JL, Shochat T, Marler M, Corey-Bloom J, Levi L. Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer’s disease patients. Behav. Sleep Med. 2003;1:22–36. - PubMed
    1. Antoniadis EA, Ko CH, Ralph MR, McDonald RJ. Circadian rhythms, aging and memory. Behav. Brain Res. 2000;111:25–37. - PubMed
    1. Asher G, Sassone-Corsi P. Time for food: The intimate interplay between nutrition, metabolism, and the circadian clock. Cell. 2015;161:84–92. - PubMed
    1. Bass J, Takahashi JS. Circadian integration of metabolism and energetics. Science. 2010;330:1349–1354. - PMC - PubMed