Epigenetics and Common Ophthalmic Diseases
- PMID: 28018148
- PMCID: PMC5168835
Epigenetics and Common Ophthalmic Diseases
Abstract
The study of ocular diseases and epigenetic dysregulation is an emerging area of research. The knowledge from the epigenetic mechanisms of DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs regarding the pathogenesis of ocular diseases will be helpful for improved treatment modalities for our patients. In particular, we focus upon the how epigenetic regulatory mechanisms impact five common ocular diseases: age related macular degeneration, age-related cataract, pterygium, retinoblastoma, and uveal melanoma. Hence, the foundation of this research paves the way for future specific therapeutic targets to treat and prevent vision loss.
Keywords: Age-related macular degeneration; cataract; epigenetics; pterygium; retinoblastoma; uveal melanoma.
Similar articles
-
Role of Epigenetics in Uveal Melanoma.Int J Biol Sci. 2017 Mar 11;13(4):426-433. doi: 10.7150/ijbs.18331. eCollection 2017. Int J Biol Sci. 2017. PMID: 28529451 Free PMC article. Review.
-
Spatial intratumor heterogeneity in uveal melanoma: Tumor cell subtypes with a presumed invasive potential exhibit a particular epigenetic staining reaction.Exp Eye Res. 2019 May;182:175-181. doi: 10.1016/j.exer.2019.04.001. Epub 2019 Apr 4. Exp Eye Res. 2019. PMID: 30954503
-
Skewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma.Invest Ophthalmol Vis Sci. 2015 Jan 15;56(3):1447-58. doi: 10.1167/iovs.14-15250. Invest Ophthalmol Vis Sci. 2015. PMID: 25593028 Free PMC article.
-
Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma.Prog Retin Eye Res. 2022 Jul;89:101030. doi: 10.1016/j.preteyeres.2021.101030. Epub 2021 Dec 1. Prog Retin Eye Res. 2022. PMID: 34861419 Review.
-
DNA Methylation and Uveal Melanoma.Chin Med J (Engl). 2018 Apr 5;131(7):845-851. doi: 10.4103/0366-6999.228229. Chin Med J (Engl). 2018. PMID: 29578129 Free PMC article. Review.
Cited by
-
Design of Intelligent Diagnosis and Treatment System for Ophthalmic Diseases Based on Deep Neural Network Model.Contrast Media Mol Imaging. 2022 Jul 5;2022:4934190. doi: 10.1155/2022/4934190. eCollection 2022. Contrast Media Mol Imaging. 2022. Retraction in: Contrast Media Mol Imaging. 2023 Jul 19;2023:9813607. doi: 10.1155/2023/9813607. PMID: 35854765 Free PMC article. Retracted.
-
Systematic review of differential methylation in rare ophthalmic diseases.BMJ Open Ophthalmol. 2019 Nov 13;4(1):e000342. doi: 10.1136/bmjophth-2019-000342. eCollection 2019. BMJ Open Ophthalmol. 2019. PMID: 31799411 Free PMC article. Review.
-
The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration.Cells. 2020 Mar 10;9(3):674. doi: 10.3390/cells9030674. Cells. 2020. PMID: 32164325 Free PMC article. Review.
-
Atypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis.Invest Ophthalmol Vis Sci. 2022 Apr 1;63(4):17. doi: 10.1167/iovs.63.4.17. Invest Ophthalmol Vis Sci. 2022. PMID: 35472218 Free PMC article.
-
Epigenetics-Shedding Light on the Path Ahead for Material Sciences.Diseases. 2019 Jun 14;7(2):43. doi: 10.3390/diseases7020043. Diseases. 2019. PMID: 31208004 Free PMC article.
References
-
- Holliday R. Epigenetics: A Historical Overview. Epigenetics. 2006;1:76–80. - PubMed
-
- Franchini DM, Schmitz KM, Petersen-Mahrt SK. 5-Methylcytosine DNA Methylation: More than losing a methyl group. Annu Rev Genet. 2012;46:419–441. - PubMed
-
- Costello JF, Fruhwald MC, Smiraglia DJ. et al. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet. 2000;24(2):132–138. - PubMed
-
- Suganuma T, Workman JL. Signals and combinatorial functions of histone modifications. Annu Rev Biochem. 2011;80:473–499. - PubMed
-
- Kouzarides T. Chromatin modifications and their function. Cell. 2007;128(4):693–705. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources