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Case Reports
. 2016 Nov-Dec;21(6):518-521.
doi: 10.5863/1551-6776-21.6.518.

Antenatal Escitalopram Use and Necrotizing Enterocolitis in a Newborn: A Case Report

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Case Reports

Antenatal Escitalopram Use and Necrotizing Enterocolitis in a Newborn: A Case Report

Nilima Jawale et al. J Pediatr Pharmacol Ther. 2016 Nov-Dec.

Abstract

The increased use of antidepressants during pregnancy has been associated with adverse effects in the newborn. We report a case of antenatal escitalopram use associated with necrotizing enterocolitis in a healthy term baby. We further discuss possible mechanisms that may explain this association. With increasing evidence of association of necrotizing enterocolitis with maternal exposure to antidepressants, more studies to find out causality and methods to predict babies at risk and their prudent management are needed.

Keywords: SSRIs; escitalopram; necrotizing enterocolitis; pregnancy; prenatal antidepressant-exposure syndrome; selective serotonin reuptake inhibitors; term neonate.

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References

    1. Kinsella MT, Monk C.. Impact of maternal stress, depression and anxiety on fetal neurobehavioral development. Clin Obstet Gynecol. 2009; 52( 3): 425– 440. - PMC - PubMed
    1. Teixeira J, Fisk N, Glover V.. Association between maternal anxiety in pregnancy and increased uterine artery resistance index: cohort based study. BMJ. 1999; 318( 7177): 153– 157. - PMC - PubMed
    1. Moses-Kolko E, Bogen D, Perel J, . et al. Neonatal signs after late in utero exposure to serotonin reuptake inhibitors. JAMA. 2005; 293( 19): 2372– 2383. - PubMed
    1. Gentile S. On categorizing gestational, birth, and neonatal complications following late pregnancy exposure to antidepressants: the prenatal antidepressant exposure syndrome. CNS Spectr. 2010; 15( 3): 167– 185. - PubMed
    1. Malm H, Sourander A, Gissler M, . et al. Pregnancy complications following prenatal exposure to SSRIs or maternal psychiatric disorders: results from population-based national register data. Am J Psychiatry. 2015; 172( 12): 1224– 1232. - PubMed

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