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. 2016 Nov;59(Suppl 1):S68-S71.
doi: 10.3345/kjp.2016.59.11.S68. Epub 2016 Nov 30.

Acute gastritis associated with Epstein-Barr virus infection in a child

Ji Mok Kim  1 , Chun Woo Song  1 , Kyu Sang Song  2 , Jae Young Kim  3
Affiliations

Acute gastritis associated with Epstein-Barr virus infection in a child

Ji Mok Kim et al. Korean J Pediatr. 2016 Nov.

Abstract

Infectious mononucleosis is Epstein-Barr virus (EBV) inducing a self-limiting clinical syndrome characterized by fever, sore throat, hepatosplenomegaly, and generalized lymphadenopathy. Gastrointestinal symptoms of EBV infection are nonspecific and occur rarely. EBV inducing acute gastrointestinal pathology is poorly recognized without suspicion. Careful consideration is needed to diagnose gastric involvement of EBV infection including gastric lymphoma, gastric cancer, and gastritis. A few recent cases of gastritis associated with EBV infection have been reported in adolescents and adults. However, there is no report of EBV-associated gastritis in early childhood. We experienced a rare case of 4-year-old girl with EBV gastritis confirmed by in situ hybridization.

Keywords: Epstein-Barr virus; Gastritis; In situ hybridization; Infectious mononucleosis.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Diffuse wall thickening of the stomach (*) detected by computed topographic scan (A), and diffuse edematous gastric mucosa was noted in the body and antrum (B).
Fig. 2
Fig. 2. Microscopic findings. (A) There is diffuse atypical lymphocytes proliferation in the lamina propria (H&E, ×100). (B, C) These cells are positive for CD20 (B) and CD3 (C) (immunohistochemistry, ×200). (D) It shows also positive for Epstein-Barr virus-encoded small RNA staining (in situ hybridization method, ×200)
See this image and copyright information in PMC

References

    1. Zhang Y, Molot R. Severe gastritis secondary to Epstein-Barr viral infection. Unusual presentation of infectious mononucleosis and associated diffuse lymphoid hyperplasia in gastric mucosa. Arch Pathol Lab Med. 2003;127:478–480. - PubMed
    1. Rea TD, Russo JE, Katon W, Ashley RL, Buchwald DS. Prospective study of the natural history of infectious mononucleosis caused by Epstein-Barr virus. J Am Board Fam Pract. 2001;14:234–242. - PubMed
    1. Markin RS. Manifestations of Epstein-Barr virus-associated disorders in liver. Liver. 1994;14:1–13. - PubMed
    1. Owens SR, Walls A, Krasinskas AM, Rund CR. Epstein-Barr virus gastritis: rare or rarely sampled? A case report. Int J Surg Pathol. 2011;19:196–198. - PubMed
    1. Chen ZM, Shah R, Zuckerman GR, Wang HL. Epstein-Barr virus gastritis: an underrecognized form of severe gastritis simulating gastric lymphoma. Am J Surg Pathol. 2007;31:1446–1451. - PubMed

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