Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016:2016:2532108.
doi: 10.1155/2016/2532108. Epub 2016 Nov 29.

Low Serum Levels of Prealbumin, Retinol Binding Protein, and Retinol Are Frequent in Adult Type 1 Diabetic Patients

Luis Forga  1 , Federico Bolado  2 , María José Goñi  1 , Ibai Tamayo  3 , Berta Ibáñez  4 , Carlos Prieto  2
Affiliations

Low Serum Levels of Prealbumin, Retinol Binding Protein, and Retinol Are Frequent in Adult Type 1 Diabetic Patients

Luis Forga et al. J Diabetes Res. 2016.

Abstract

Aim. To determine the serum prealbumin (PA), retinol binding protein (RBP), and retinol levels in adult patients with type 1 diabetes (T1D) and to analyze some factors related to those levels. Methods. A total of 93 patients (47 women) were studied. Age, gender, BMI, duration of diabetes, chronic complications, HbA1c, lipid profile, creatinine, albumin, PA, RBP, and retinol were recorded. High and low parameter groups were compared by Mann-Whitney U and χ2 tests. Correlation between parameters was analyzed by Spearman's test. Odds of low levels were analyzed by univariate logistic regression and included in the multivariate analysis when significant. Results. 49.5%, 48.4%, and 30.1% of patients displayed serum PA, RBP, and retinol levels below normal values, respectively. A high correlation (Rho > 0.8) between PA, RBP, and retinol serum levels was found. Patients presenting low levels of any of them were predominantly women, normal-weighted, and with lower levels of triglycerides and serum creatinine. No differences in age, macrovascular complications, duration of diabetes, or HbA1c values were observed when comparing low and normal parameter groups. Conclusion. Low serum levels of PA, RBP, and retinol are frequent in T1D adult patients. This alteration is influenced by female sex and serum creatinine and triglyceride levels.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

Figures

Figure 1
Figure 1
Correlation between PA, RBP, and retinol levels.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Refai E., Dekki N., Yang S.-N., et al. Transthyretin constitutes a functional component in pancreatic β-cell stimulus-secretion coupling. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(47):17020–17025. doi: 10.1073/pnas.0503219102. - DOI - PMC - PubMed
    1. Itoh N., Hanafusa T., Miyagawa J.-I., et al. Transthyretin (prealbumin) in the pancreas and sera of newly diagnosed type I (insulin-dependent) diabetic patients. Journal of Clinical Endocrinology and Metabolism. 1992;74(6):1372–1377. doi: 10.1210/jc.74.6.1372. - DOI - PubMed
    1. Baena R. M., Campoy C., Bayés R., Blanca E., Fernández J. M., Molina-Font J. A. Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus. European Journal of Clinical Nutrition. 2002;56(1):44–50. doi: 10.1038/sj/ejcn/1601279. - DOI - PubMed
    1. Gebre-Medhin M., Kylberg E., Ewald U., Tuvemo T. Dietary intake, trace elements and serum proteína status in young diabetics. Acta paediatrica Scandinavica. Supplement. 1985;320:38–43. - PubMed
    1. Tuvemo T., Ewald U., Kobbah M., Proos L. A. Serum magnesium and protein concentrations during the first five years of insulin-dependent diabetes in children. Acta Paediatrica. 1997;86(supplement 418):7–10. doi: 10.1111/j.1651-2227.1997.tb18297.x. - DOI - PubMed