Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use

Affiliations

¹ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Hospital Epidemiology and Infection Control, Suburban Hospital, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
³ Microbiology Laboratory, The Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
⁴ Department of Geriatrics, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
⁵ Suburban Hospital, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
⁶ Division of Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: tperl@jhmi.edu.
⁷ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Microbiology Laboratory, The Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address: szhang28@jhmi.edu.

PMID: 28024866
DOI: 10.1016/j.diagmicrobio.2016.12.004

Case Reports

Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use

Isabella W Martin et al. Diagn Microbiol Infect Dis. 2017 Mar.

. 2017 Mar;87(3):286-288.

doi: 10.1016/j.diagmicrobio.2016.12.004. Epub 2016 Dec 16.

Authors

Affiliations

¹ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Hospital Epidemiology and Infection Control, Suburban Hospital, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
³ Microbiology Laboratory, The Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
⁴ Department of Geriatrics, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
⁵ Suburban Hospital, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
⁶ Division of Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: tperl@jhmi.edu.
⁷ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Microbiology Laboratory, The Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address: szhang28@jhmi.edu.

PMID: 28024866
DOI: 10.1016/j.diagmicrobio.2016.12.004

Abstract

We report a case of fungemia in an immunocompetent patient after administration of probiotic containing Saccharomyces boulardii. We demonstrated the strain relatedness of the yeast from the probiotic capsule and the yeast causing fungal infection using genomic and proteomic typing methods. Our study questions the safety of this preventative biotherapy.

Keywords: Fungal infection; Fungemia; Probiotic; Saccharomyces boulardii; Strain typing.

PubMed Disclaimer

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use

Affiliations

Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources