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. 2017 Feb:103:123-128.
doi: 10.1016/j.micpath.2016.12.019. Epub 2016 Dec 23.

Evaluation of anti-cholinesterase, antibacterial and cytotoxic activities of green synthesized silver nanoparticles using from Millettia pinnata flower extract

Govindasamy Rajakumar  1 , Thandapani Gomathi  2 , Muthu Thiruvengadam  1 , V Devi Rajeswari  3 , V N Kalpana  3 , Ill-Min Chung  4
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Evaluation of anti-cholinesterase, antibacterial and cytotoxic activities of green synthesized silver nanoparticles using from Millettia pinnata flower extract

Govindasamy Rajakumar et al. Microb Pathog. 2017 Feb.

Abstract

The aim of this study is to develop an easy and eco-friendly method for the synthesis of Ag-NPs using extracts from the medicinal plant, Millettia pinnata flower extract and investigate the effects of Ag-NPs on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), antibacterial and cytotoxicity activity. UV-Vis peak at 438 nm confirmed the Ag-NPs absorbance. The SEM analysis results confirmed the presence of spherical shaped Ag-NPs by a huge disparity in the particle size distribution with an average size of 49 ± 0.9 nm. TEM images revealed the formation of Ag-NPs with spherical shape and sizes in the range between 16 and 38 nm. The Ag-NPs showed an excellent inhibitory efficacy against AChE and BChE. The highest antibacterial activity was found against Escherichia coli (20.25 ± 0.91 mm). These nanoparticles showed the cytotoxic effects against brine shrimp (artemia saliana) nauplii with a LD50 value of 33.92.

Keywords: Anti-cholinesterase; Antibacteria; Electron microscopy; Millettia pinnata; Silver nanoparticles.

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