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. 1989 Sep;26(3):331-5.
doi: 10.1002/ana.410260304.

Increased replication of HTLV-I in HTLV-I-associated myelopathy

M Yoshida  1 , M Osame, H Kawai, M Toita, N Kuwasaki, Y Nishida, Y Hiraki, K Takahashi, K Nomura, S Sonoda, et al.
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Increased replication of HTLV-I in HTLV-I-associated myelopathy

M Yoshida et al. Ann Neurol. 1989 Sep.

Abstract

To estimate the replication of the human T-cell leukemia virus type I (HTLV-I) in patients with HTLV-I-associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV-I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization. HTLV-I DNA was detected in 125 (82%) of 153 patients and most showed random integration. This incidence was much higher than the 29% found in asymptomatic carriers. Therefore, HAM/TSP development is associated with a high level of HTLV-I replication. In addition, lymphocytes from 3 patients with HAM/TSP showed monoclonal integration of HTLV-I DNA, indicating adult T-cell leukemia.

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