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. 1989 Aug;33(8):1406-8.
doi: 10.1128/AAC.33.8.1406.

Pharmacokinetics of amikacin in hematologic malignancies

S Kaojarern  1 , S Maoleekoonpairoj, V Atichartakarn
Affiliations

Pharmacokinetics of amikacin in hematologic malignancies

S Kaojarern et al. Antimicrob Agents Chemother. 1989 Aug.

Abstract

The pharmacokinetics of amikacin in 10 patients with hematologic malignancies and 1 patient with aplastic anemia were investigated. At an administered dose of 7 mg/kg of body weight, a volume of distribution of 0.4 liters/kg, an elimination half-life of 3.0 h, and a total body clearance of 2.1 ml/min per kg, amikacin achieved a peak level in blood of 21 micrograms/ml. Results of the study revealed that there was a marked increase in volume of distribution of amikacin in these patients compared with normal.

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