Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar;367(3):643-649.
doi: 10.1007/s00441-016-2539-y. Epub 2016 Dec 26.

Pulmonary vascular remodeling in pulmonary hypertension

Rubin M Tuder  1
Affiliations
Review

Pulmonary vascular remodeling in pulmonary hypertension

Rubin M Tuder. Cell Tissue Res. 2017 Mar.

Abstract

Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension and involves changes in the intima, media and adventitia, often with the interplay of inflammatory cells. This review examines the pathology of these changes and highlights some of the pathogenetic mechanisms that underlie the remodeling process.

Keywords: Endothelial cells; Lung; Pulmonary hypertension; Pulmonary remodeling; Smooth muscle cells.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A. Moderately thickened pulmonary arteries (arrows) in a normal lung, obtained as a potential graft. B. Exuberant plexiform lesion (arrows) with whorls of endothelial cells with abnormally organized blood vessel lumina. C. Pulmonary artery in PAH with marked intima obliteration (arrow). D. Small cluster of endothelial cells, consistent with incipient plexiform lesion (arrow), surrounded by cells organized in concentric pattern (small arrows). E. Pulmonary artery with cellular and mucoid intima thickening (arrow). F. Marked inflammation around and within plexiform lesion (arrow).
See this image and copyright information in PMC

References

    1. Abe K, Toba M, Alzoubi A, Ito M, Fagan KA, Cool CD, Voelkel NF, McMurtry IF, Oka M. Formation of plexiform lesions in experimental severe pulmonary arterial hypertension. Circulation. 2010;121:2747–2754. - PubMed
    1. Archer SL, Weir EK, Wilkins MR. Basic Science of Pulmonary Arterial Hypertension for Clinicians: New Concepts and Experimental Therapies. Circulation. 2010;121:2045–2066. - PMC - PubMed
    1. Bjornsson J, Edwards WD. Primary pulmonary hypertension: a histopathologic study of 80 cases. Mayo Clin Proc. 1985;60:16–25. - PubMed
    1. Caslin AW, Heath D, Madden B, Yacoub M, Gosney JR, Smith P. The histopathology of 36 cases of plexogenic pulmonary arteriopathy. Histopathology. 1990;16:9–19. - PubMed
    1. Chazova I, Loyd JE, Newman JH, Belenkov Y, Meyrick B. Pulmonary artery adventitial changes and venous involvement in primary pulmonary hypertension. American Journal of Pathology. 1995;146:389–397. - PMC - PubMed

Publication types

LinkOut - more resources