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Review
. 2017 May;40(5):287-291.
doi: 10.1002/clc.22657. Epub 2016 Dec 27.

Impact of diabetes on mortality in peripheral artery disease: a meta-analysis

Mislav Vrsalovic  1   2 , Ksenija Vucur  3 , Ana Vrsalovic Presecki  4 , Damir Fabijanic  5 , Milan Milosevic  1   6
Affiliations
Review

Impact of diabetes on mortality in peripheral artery disease: a meta-analysis

Mislav Vrsalovic et al. Clin Cardiol. 2017 May.

Abstract

Background: There are accumulating studies showing the association between diabetes and all-cause mortality in peripheral vascular disease. However, the results in these studies are conflicting regarding the impact of diabetes on outcome.

Hypothesis: Diabetes is associated with increased risk of mortality in peripheral artery disease.

Methods: Using MEDLINE and Scopus, we searched for studies published before January 2016. Additionally, studies were identified by manual search of references of original articles or review studies on this topic. Of the 1072 initially identified records, 21 studies with 15,857 patients were included in the final analysis.

Results: Diabetes was associated with a statistically significant increased risk of all-cause mortality (odds ratio: 1.89, 95% confidence interval: 1.51-2.35, P < 0.001), without detected publication bias (Egger bias = 0.75, P = 0.631). The stronger effect on outcome was obtained in patients with critical limb ischemia (odds ratio: 2.38, 95% confidence interval: 1.22-4.63, P < 0.001) as the most severe form of peripheral vascular disease.

Conclusions: Diabetes is associated with an increased risk of mortality in peripheral vascular disease, and the effect is even more pronounced in patients with critical limb ischemia.

Keywords: critical limb ischemia; diabetes; meta-analysis; mortality; peripheral artery disease.

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Conflict of interest statement

The authors declare no potential conflict of interests.

Figures

Figure 1
Figure 1
Study flow diagram.
Figure 2
Figure 2
Meta‐analysis (random effects model) testing the association between diabetes and all‐cause mortality in (a) all studies with peripheral artery disease, (b) prospective studies with performed multivariate analysis without critical limb ischemia, (c) all studies with critical limb ischemia, and (d) Caucasian studies with critical limb ischemia.
See this image and copyright information in PMC

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