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. 1989 Sep;55(9):2275-9.
doi: 10.1128/aem.55.9.2275-2279.1989.

Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans

C E Cerniglia  1 , W L Campbell, J P Freeman, F E Evans
Affiliations

Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans

C E Cerniglia et al. Appl Environ Microbiol. 1989 Sep.

Abstract

The metabolism of phenanthrene by the fungus Cunninghamella elegans was investigated. Kinetic experiments using [9-14C]phenanthrene showed that after 72 h, 53% of the total radioactivity was associated with a glucoside conjugate of 1-hydroxyphenanthrene (phenanthrene 1-O-beta-glucose). This metabolite was isolated by reversed-phase high-performance liquid chromatography and characterized by the application of UV absorption, 1H nuclear magnetic resonance, and mass spectral techniques. The results show that aromatic ring oxidation followed by glucosylation is a predominant pathway in the metabolism of the polycyclic aromatic hydrocarbon phenanthrene by C. elegans.

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