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. 2017 Jan 20;82(2):1240-1247.
doi: 10.1021/acs.joc.6b02426. Epub 2017 Jan 11.

One-Pot Synthesis of Rotationally Restricted, Conjugatable, BODIPY Derivatives from Phthalides

Mayca Del Río  1 , Fernando Lobo  1 , J Cristobal López  1 , Ainhoa Oliden  2 , Jorge Bañuelos  2 , Iñigo López-Arbeloa  2 , Inmaculada Garcia-Moreno  3 , Ana M Gómez  1
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One-Pot Synthesis of Rotationally Restricted, Conjugatable, BODIPY Derivatives from Phthalides

Mayca Del Río et al. J Org Chem. .

Abstract

O-Ethylation of phthalides with Meerwein's reagent followed by reaction of the ensuing salts with pyrrole, results in the formation of 5-alkoxy-5-phenyl dipyrromethane derivatives, which function as ready precursors of ortho-substituted 8-aryl BODIPY derivatives by reaction with borontrifluoride etherate, an overall process that can be carried out in a one-pot operation.

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