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Comment
. 2016 Dec 28;49(1):5-6.
doi: 10.1038/ng.3754.

Copy number alterations unmasked as enhancer hijackers

Rameen Beroukhim  1 , Xiaoyang Zhang  1 , Matthew Meyerson  1
Affiliations
Comment

Copy number alterations unmasked as enhancer hijackers

Rameen Beroukhim et al. Nat Genet. .

Abstract

Our understanding of how DNA copy number changes contribute to disease, including cancer, has to a large degree been focused on the changes in gene dosage that they generate and has neglected the effects of the DNA rearrangements that lead to their formation. A new study reports an innovative analytical framework for copy number alterations that are oncogenic primarily owing to the genomic rearrangements that underlie them.

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  • Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.
    Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stütz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R, Peifer M, Helland A, Ball CR, Jechlinger M, Sotillo R, Glimm H, Korbel JO. Weischenfeldt J, et al. Nat Genet. 2017 Jan;49(1):65-74. doi: 10.1038/ng.3722. Epub 2016 Nov 21. Nat Genet. 2017. PMID: 27869826 Free PMC article.

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