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Comment
. 2016 Dec 28;49(1):2-3.
doi: 10.1038/ng.3759.

Is a super-enhancer greater than the sum of its parts?

Noah Dukler  1 , Brad Gulko  1   2 , Yi-Fei Huang  1 , Adam Siepel  1
Affiliations
Comment

Is a super-enhancer greater than the sum of its parts?

Noah Dukler et al. Nat Genet. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing Financial Interests. The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
(A) Model fit for the α-globin (blue) and Wap (green) data sets, measured as the Bayesian Information Criterion (BIC) for the additive model minus the BIC for the additive (0 by definition), linear-exponential, and linear-logistic models. (B) Predicted expression at the α-globin locus (black line, with blue boundaries indicating 0.05–0.95 quantiles) under the best-fitting linear-logistic model. The actual data points are shown in red, with replicates aligned vertically. (C) Same for the Wap locus. In (B) and (C), the wild-type configuration appears as the collection of data points farthest to the right. Notice that the definition of the x-axis depends on the linear coefficients estimated for each model. (D) Model fit, measured by BIC, for the Wap data set for the linear-logistic model shown in (A) relative to alternative models with interaction terms for either E1a & E2 or E2 & E3.
See this image and copyright information in PMC

Comment on

  • Genetic dissection of the α-globin super-enhancer in vivo.
    Hay D, Hughes JR, Babbs C, Davies JOJ, Graham BJ, Hanssen L, Kassouf MT, Marieke Oudelaar AM, Sharpe JA, Suciu MC, Telenius J, Williams R, Rode C, Li PS, Pennacchio LA, Sloane-Stanley JA, Ayyub H, Butler S, Sauka-Spengler T, Gibbons RJ, Smith AJH, Wood WG, Higgs DR. Hay D, et al. Nat Genet. 2016 Aug;48(8):895-903. doi: 10.1038/ng.3605. Epub 2016 Jul 4. Nat Genet. 2016. PMID: 27376235 Free PMC article.
  • Hierarchy within the mammary STAT5-driven Wap super-enhancer.
    Shin HY, Willi M, HyunYoo K, Zeng X, Wang C, Metser G, Hennighausen L. Shin HY, et al. Nat Genet. 2016 Aug;48(8):904-911. doi: 10.1038/ng.3606. Epub 2016 Jul 4. Nat Genet. 2016. PMID: 27376239 Free PMC article.

References

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    1. Shin HY, et al. Hierarchy within the mammary STAT5-driven Wap super-enhancer. Nat Genet. 2016;48:904–911. - PMC - PubMed
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