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. 1989 Oct;124(10):1174-8; discussion 1178-9.
doi: 10.1001/archsurg.1989.01410100076013.

Local control in rectal cancer. A clinical review and meta-analysis

P Twomey  1 , M Burchell, D Strawn, J Guernsey
Affiliations

Local control in rectal cancer. A clinical review and meta-analysis

P Twomey et al. Arch Surg. 1989 Oct.

Abstract

We reviewed the factors influencing local control of potentially curable rectal cancer in 106 patients. There was improvement in stage-adjusted local control associated with increasing use of adjuvant radiation therapy. A meta-analysis of the English-language literature through 1988 also supported the effectiveness of adjuvant radiation therapy in all but the lowest-risk patients. No effect on survival was identified in either analysis, but a reduction of up to 40% in local recurrence rates may be achieved with doses of 3000 cGy or more.

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