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. 2017 Apr 1;152(4):336-342.
doi: 10.1001/jamasurg.2016.4753.

Defining a Hospital Volume Threshold for Minimally Invasive Pancreaticoduodenectomy in the United States

Mohamed Abdelgadir Adam  1 , Samantha Thomas  2 , Linda Youngwirth  1 , Theodore Pappas  1 , Sanziana A Roman  1 , Julie A Sosa  3
Affiliations

Defining a Hospital Volume Threshold for Minimally Invasive Pancreaticoduodenectomy in the United States

Mohamed Abdelgadir Adam et al. JAMA Surg. .

Abstract

Importance: There is increasing interest in expanding use of minimally invasive pancreaticoduodenectomy (MIPD). This procedure is complex, with data suggesting a significant association between hospital volume and outcomes.

Objective: To determine whether there is an MIPD hospital volume threshold for which patient outcomes could be optimized.

Design, setting, and participants: Adult patients undergoing MIPD were identified from the Healthcare Cost and Utilization Project National Inpatient Sample from 2000 to 2012. Multivariable models with restricted cubic splines were used to identify a hospital volume threshold by plotting annual hospital volume against the adjusted odds of postoperative complications. The current analysis was conducted on August 16, 2016.

Main outcomes and measures: Incidence of any complication.

Results: Of the 865 patients who underwent MIPD, 474 (55%) were male and the median patient age was 67 years (interquartile range, 59-74 years). Among the patients, 747 (86%) had cancer and 91 (11%) had benign conditions/pancreatitis. Overall, 410 patients (47%) had postoperative complications and 31 (4%) died in-hospital. After adjustment for demographic and clinical characteristics, increasing hospital volume was associated with reduced complications (overall association P < .001); the likelihood of experiencing a complication declined as hospital volume increased up to 22 cases per year (95% CI, 21-23). Median hospital volume was 6 cases per year (range, 1-60). Most patients (n = 717; 83%) underwent the procedure at low-volume (≤22 cases per year) hospitals. After adjustment for patient mix, undergoing MIPD at low- vs high-volume hospitals was significantly associated with increased odds for postoperative complications (odds ratio, 1.74; 95% CI, 1.03-2.94; P = .04).

Conclusions and relevance: Hospital volume is significantly associated with improved outcomes from MIPD, with a threshold of 22 cases per year. Most patients undergo MIPD at low-volume hospitals. Protocols outlining minimum procedural volume thresholds should be considered to facilitate safer dissemination of MIPD.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Sosa is a member of the Data Monitoring Committee of the Medullary Thyroid Cancer Consortium Registry supported by Novo Nordisk, GlaxoSmithKline, AstraZeneca, and Eli Lilly. No other disclosures were reported.

Figures

Figure.
Figure.. Smoothed Restricted Cubic Spline Plot of the Adjusted Log Odds Ratio of Experiencing Any Complication vs the Annual Number of Minimally Invasive Pancreaticoduodenectomy Cases Performed per Hospital
The curved line with long dashes represents the regression line in the change point estimation. The 2 lighter dotted curves represent the 95% CIs. The black dots correspond to the location of 3 knots used in the model. The intersection at the value of 22 cases per year (dotted blue vertical line) is the cutoff identified by the model, with adjustment for the effects of patient age, sex, race/ethnicity, comorbidities, year of diagnosis, and clinical diagnosis.
See this image and copyright information in PMC

Comment in

References

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