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Review
. 2017 Feb 28;91(6):e02338-16.
doi: 10.1128/JVI.02338-16. Print 2017 Mar 15.

Unraveling the Armor of a Killer: Evasion of Host Defenses by African Swine Fever Virus

Ana Luisa Reis  1 , Chris Netherton  1 , Linda K Dixon  2
Affiliations
Review

Unraveling the Armor of a Killer: Evasion of Host Defenses by African Swine Fever Virus

Ana Luisa Reis et al. J Virol. .

Abstract

African swine fever is an acute hemorrhagic disease of pigs. Extensive recent spread in the Russian Federation and Eastern Europe has increased the risk to global pig production. The virus is a large DNA virus and is the only member of the Asfarviridae family. In pigs, the virus replicates predominantly in macrophages. We review how the virus overcomes the barriers to replication in the macrophage and the virus mechanism to inhibit key host defense pathways.

Keywords: African swine fever; apoptosis; immune evasion; interferon; protein synthesis.

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Figures

FIG 1
FIG 1
African swine fever virus in spleen samples from pigs infected with virulent virus. Pigs were infected with the virulent ASFV Benin 97/1 isolate, and after 3 days pigs were euthanized and tissue samples were collected. A section of infected spleen is shown with the myeloid-specific cell surface marker SWC3 (CD172a) labeled in green and the ASFV p54 protein in red. Bar, 30 μm. (Image courtesy of Pippa Hawes, Pirbright Institute, reproduced with permission.)
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References

    1. Costard S, Wieland B, de Glanville W, Jori F, Rowlands R, Vosloo W, Roger F, Pfeiffer DU, Dixon LK. 2009. African swine fever: how can global spread be prevented? Philos Trans R Soc Lond B Biol Sci 364:2683−2696. doi:10.1098/rstb.2009.0098. - DOI - PMC - PubMed
    1. Hernáez B, Guerra M, Salas ML, Andres G. 2016. African swine fever virus undergoes outer envelope disruption, capsid disassembly and inner envelope fusion before core release from multivesicular endosomes. PLoS Pathog 12:e1005595. doi:10.1371/journal.ppat.1005595. - DOI - PMC - PubMed
    1. Redrejo-Rodríguez M, Salas ML. 2014. Repair of base damage and genome maintenance in the nucleo-cytoplasmic large DNA viruses. Virus Res 179:12–25. doi:10.1016/j.virusres.2013.10.017. - DOI - PubMed
    1. Granja AG, Sabina P, Salas ML, Fresno M, Revilla Y. 2006. Regulation of inducible nitric oxide synthase expression by viral A238L-mediated inhibition of p65/RelA acetylation and p300 transactivation. J Virol 80:10487–10496. doi:10.1128/JVI.00862-06. - DOI - PMC - PubMed
    1. Revilla Y, Cebrian A, Baixeras E, Martinez C, Vinuela E, Salas ML. 1997. Inhibition of apoptosis by the African swine fever virus bcl-2 homologue: role of the BH1 domain. Virology 228:400–404. doi:10.1006/viro.1996.8395. - DOI - PubMed

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