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Case Reports
. 2015 Nov 1;1(3):FSO18.
doi: 10.4155/fso.15.16. eCollection 2015 Nov.

Primary squamous cell carcinoma of the prostate: a case report of a rare clinical entity

Tithi Biswas  1 , Tarun Podder  1 , Pamela A Lepera  2 , Paul Walker  2
Affiliations
Case Reports

Primary squamous cell carcinoma of the prostate: a case report of a rare clinical entity

Tithi Biswas et al. Future Sci OA. .

Abstract

Primary squamous cell carcinoma of the prostate is a unique and rare clinicopathological entity with fewer than 100 cases reported in the literature. Because of its rarity, the optimal management is not well known. Here, we report a case of primary squamous cell carcinoma of the prostate which was treated with definitive concurrent chemo-radiotherapy with excellent outcome along with a brief review of the literature.

Keywords: chemo-radiation; squamous cell carcinoma of prostate.

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Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

Figures

<b>Figure 1.</b>
Figure 1.. Pre-treatment biopsy, and imaging studies.
(A) Initial biopsy from the rectal mass showing squamous cell carcinoma on H&E stain (high power microscopy). (B) (axial and coronal views) Initial staging positron emission tomography-CT scan showing hypermetabolic tumor involving prostate gland (green arrow) and the compressed rectum (red arrow). (C) Radiotherapy planning CT scan showing the abnormal looking prostate gland (green arrow) with rectum (red arrow) being pushed.
<b>Figure 2.</b>
Figure 2.. Post-treatment imaging studies and biopsy result.
(A) Post-treatment positron emission tomography-CT scan showing complete metabolic response following completion of therapy. (B&C) Post-treatment CT and MRI scan showing excellent response (green arrow) to therapy with rectum in normal position (red arrow). (D) Post-treatment biopsy showing no malignant cells present (low power microscopy).
See this image and copyright information in PMC

References

    1. Munoz F, Franco P, Ciammella P, et al. Squamous cell carcinoma of the prostate: long-term survival after combined chemo-radiation. Radiat. Oncol. 2007;2:15–21. - PMC - PubMed

    2. • Good review of the literature on the topic of primary Squamous cell carcinoma of the prostate.

    1. Nabi G, Ansari MS, Singh I, Sharma MC, Dogra PN. Primary squamous cell carcinoma of the prostate: a rare clinicopathological entity. Report of 2 cases and review of literature. Urol. Int. 2001;66:216–219. - PubMed
    1. Arva NC, Das K. Diagnostic dilemmas of squamous differentiation in prostate carcinoma case report and review of the literature. Diagn. Pathol. 2011;6:46–53. - PMC - PubMed
    1. Wernert N, Goebbles R, Bonkhoff H, Dhom G. Squamous cell carcinoma of the prostate. Histopathology. 1990;17:339–344. - PubMed
    1. Malik RD, Dakwar G, Hardee ME, et al. Squamous cell carcinoma of the prostate. Rev. Urology. 2011;13:56–60. - PMC - PubMed

    2. • Good review of the literature.

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