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. 2017 Jan 17;8(3):4352-4359.
doi: 10.18632/oncotarget.13842.

Prospective study on factors affecting the prognosis of oral cancer in a Chinese population

Fengqiong Liu  1 , Fa Chen  1 , Jiangfeng Huang  1 , Lingjun Yan  1 , Fangping Liu  1 , Junfeng Wu  1 , Yu Qiu  2 , Xiaoyan Zheng  2 , Rongzhao Zhang  1 , Lisong Lin  2 , Baochang He  1
Affiliations

Prospective study on factors affecting the prognosis of oral cancer in a Chinese population

Fengqiong Liu et al. Oncotarget. .

Abstract

This study was performed to identify the factors affecting prognosis of oral cancer patients. 1240 pathologically confirmed oral cancer patients were included. The sociodemographic and clinical characteristics of all patients were collected. Univariate and multivariate Cox proportional hazards models were used to assess potential prognostic factors for survival. 1240 oral cancer patients were followed up for 49235.00 person months, and the 5-year overall survival rate was 64.38%. Both univariate and multivariate Cox regression analysis indicated that Body Mass Index < 18.5 kg/m2 (vs 18.5-23.9 kg/m2), age ≥ 55 years (vs < 55 years), clinical stages of II-IV (vs stage I), and poor differentiation (vs well differentiation) were associated with worse survival of oral cancer patients. While surgery (vs non-surgery) and origin of urban area (vs rural area) were protective factors. However, no significant association was found between adjuvant therapy and survival in oral cancer patients.

Keywords: BMI; chemotherapy; oral cancer; prognosis; radiotherapy.

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Conflict of interest statement

CONFLICTS OF INTEREST

We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled.

Figures

Figure 1
Figure 1. Ten-year survival of patients diagnosed with oral cancer in The First Affiliated Hospital of Fujian Medical University (Long-rank Mantel–Cox test)
(A) Survival analysis according to clinical stage (stage I, II, III, IV), P < 0.001 by log rank test. (B) Survival analysis according to histological grade (poorly, moderately and well differentiated), P = 0.001. (C) Survival analysis according to BMI (< 18.5,18.5–23.9, ≥ 24 kg/m2), P = 0.006. (D) Survival analysis according to age(< 55, ≥ 55 years old), P < 0.001. (E) Survival analysis according to origin (rural area, urban area), P = 0.028. (F) Survival analysis according to surgery(with or without surgery), P < 0.001. (G) Survival analysis according to treatment(surgery alone, surgery +chemotherapy, surgery +radiotherapy, surgery + chemoradiotherapy, and P = 0.211.
See this image and copyright information in PMC

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