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. 2016 Dec 29;14(1):18-22.
doi: 10.1038/nmeth.4111.

Reversible RNA modifications in meiosis and pluripotency

Arne Klungland  1   2   3 , John Arne Dahl  1 , Gareth Greggains  4 , Peter Fedorcsak  4 , Adam Filipczyk  1   3
Affiliations

Reversible RNA modifications in meiosis and pluripotency

Arne Klungland et al. Nat Methods. .

Abstract

Post-transcriptional RNA modifications were discovered several decades ago, but the reversible nature of RNA modifications has only recently been discovered. Owing to technological advances, knowledge of epitranscriptomic marks and their writers, readers and erasers has recently advanced tremendously. Here we focus on the roles of the dynamic methylation and demethylation of internal adenosines in mRNA in germ cells and pluripotent stem cells.

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References

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