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. 1989 Sep 1;262(2):659-63.
doi: 10.1042/bj2620659.

Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor

J J Hsuan  1 , N Totty, M D Waterfield
Affiliations

Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor

J J Hsuan et al. Biochem J. .

Abstract

Three major autophosphorylation sites are located near the C-terminus of the epidermal growth factor receptor, but a fourth site is repeatedly detected. We report here the purification and sequencing of a tryptic peptide containing this site, Tyr-1086. Furthermore, we demonstrate that additional phosphopeptides are observed following both partial digestion and overdigestion. Finally, we show that Tyr-1086 can be phosphorylated in intact cells.

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