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. 1989 Oct 16;164(1):575-9.
doi: 10.1016/0006-291x(89)91758-0.

Sequence homology of a canine brain calcium-binding protein with calregulin and the human Ro/SS-A antigen

J H Collins  1 , Z J Xi, B H Alderson-Lang, S Treves, P Volpe
Affiliations

Sequence homology of a canine brain calcium-binding protein with calregulin and the human Ro/SS-A antigen

J H Collins et al. Biochem Biophys Res Commun. .

Abstract

A 60 kDa calcium-binding protein (CBP) was purified from canine brain and its N-terminal sequence determined to be: Glu-Pro-Ala-Ile-Tyr-Phe-Lys-Glu-Gln-Phe-Leu-Asp-Gly-Asp-Gly-X-Thr-Arg-X- Ile- Glu-Ser-Lys. This sequence is very similar to that of "Ccalregulin", a CBP of unknown function which is similar in size and appears to be present in most animal tissues. An unexpected and even more striking similarity was found with the N-terminal sequence of the human Ro/SS-A antigen, a 60 kDa protein which has long been implicated in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus. These findings suggest that the Ro/SS-A antigen is probably also a CBP.

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