Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2017 Mar;92(3):E31-E34.
doi: 10.1002/ajh.24635. Epub 2017 Feb 3.

Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia

Seethal A Jacob  1 , Enrico M Novelli  2   3 , Jeffrey S Isenberg  3   4 , Melanie E Garrett  5 , Yanxia Chu  4 , Karen Soldano  5 , Kenneth I Ataga  6 , Marilyn J Telen  7 , Allison Ashley-Koch  5 , Mark T Gladwin  3   4 , Yingze Zhang  3   4   8 , Gregory J Kato  2   3
Affiliations
Clinical Trial

Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia

Seethal A Jacob et al. Am J Hematol. 2017 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

J.S.I. serves as Chair of the Scientific Advisory Boards of Tioma Therapeutics, Inc. (St. Louis, MO) and Radiation Control Technologies, Inc. (Jersey City, NJ) and has equity interests in the same.

References

    1. Gladwin MT. Cardiovascular complications and risk of death in sickle-cell disease. Lancet. 2016;387:2565–2574. - PubMed
    1. Kato G, Steinberg MH, Gladwin MT. Intravascular Hemolysis and the Pathophysiology of Sickle Cell Disease. J Clin Invest. in press. - PMC - PubMed
    1. Isenberg JS, Romeo MJ, Yu C, et al. Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. Blood. 2008;111:613–623. - PMC - PubMed
    1. Brittain JE, Han J, Ataga KI, et al. Mechanism of CD47-induced alpha4beta1 integrin activation and adhesion in sickle reticulocytes. J Biol Chem. 2004;279:42393–42402. - PubMed
    1. Novelli EM, Kato GJ, Ragni MV, et al. Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates. Am J Hematol. 2012;87:326–330. - PMC - PubMed