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Case Reports
. 2016 Dec 15;8(12):835-839.
doi: 10.4251/wjgo.v8.i12.835.

Esophageal liposarcoma: Well-differentiated rhabdomyomatous type

Hisham M Valiuddin  1 , Arianna Barbetta  1 , Benedetto Mungo  1 , Elizabeth A Montgomery  1 , Daniela Molena  1
Affiliations
Case Reports

Esophageal liposarcoma: Well-differentiated rhabdomyomatous type

Hisham M Valiuddin et al. World J Gastrointest Oncol. .

Abstract

Rhabdomyomatous well-differentiated esophageal liposarcomas are extremely rare. As of August 2016, only one other such case has been reported in the English-language medical literature. Liposarcomas in general are one of the most common soft tissue neoplasms in adults, but the incidence of primary esophageal liposarcomas is exceptionally low. There have been only 42 reported cases of primary liposarcoma of the esophagus worldwide thus far. These malignancies are harbored within giant fibrovascular polyps, which slowly grow within the esophageal lumen causing obstructing symptoms. We hereby present the case of a 68-year-old male patient who came in with a 2-mo history of worsening intermittent dysphagia, persistent cough, and postprandial retrosternal pain. After an esophagogastroduodenoscopy, a computed tomographic scan, and a diagnostic endoscopy, complete endoscopic resection was performed of the 13 cm × 6 cm × 2.6 cm fibrovascular polyp. A literature review was done and results are presented herein.

Keywords: Endoscopy/endoscopic procedures; Esophageal cancer; Esophageal surgery; Liposarcoma; Mesenchymal tumor; Pathology esophagus.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare there is no conflict of interest related to the publication of this case report.

Figures

Figure 1
Figure 1
Barium esophagram showing an (A) obstructing intraluminal mass in the thoracic esophagus.
Figure 2
Figure 2
Computed tomographic scan of the chest (A) (B) showing a (arrowhead ) large mass traversing the length of the esophagus.
Figure 3
Figure 3
A macroscopic view of the resected giant fibrovascular polyp (13 cm × 6 cm × 2.6 cm) with uniform surface and a large single stalk.
Figure 4
Figure 4
Histologically the polyp showed a central core of adipose and fibrovascular tissue surrounded by overlying squamous mucosa. A: Hematoxylin and eosin stain × 40 identifying (arrowhead) striated muscle cells and adipose tissue within the core of the esophageal liposarcoma; B: The giant polyp is characterized by a central core of adipose and fibrovascular tissue surrounded by overlying squamous mucosa.
Figure 5
Figure 5
Immunohistology showed positive nuclear staining of lipoblasts with MDM2 confirming the diagnosis of liposarcoma.
Figure 6
Figure 6
Cell with rhabdomyomatous differentiation were focally positive for myogenin.
Figure 7
Figure 7
Rabdomyomatous differentiation is characterized by single and loose aggregates of large round cells with abundant eosinophilic cytoplasm.
See this image and copyright information in PMC

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