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Review
. 2017 Apr;16(2):205-209.
doi: 10.1111/acel.12564. Epub 2016 Dec 29.

PAPP-A: a promising therapeutic target for healthy longevity

Cheryl A Conover  1 , Claus Oxvig  2
Affiliations
Review

PAPP-A: a promising therapeutic target for healthy longevity

Cheryl A Conover et al. Aging Cell. 2017 Apr.

Abstract

Pregnancy-associated plasma protein-A (PAPP-A) is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan. Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF. Here, we will review data in support of PAPP-A as a therapeutic target to promote healthy longevity.

Keywords: IGF; PAPP-A; aging.

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Figures

Figure 1
Figure 1
Role of PAPP‐A and IGFBP‐4 in the local control of IGF signaling.
See this image and copyright information in PMC

References

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