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Clinical Trial
. 1989 Oct;68(5):215-20.
doi: 10.1097/00002060-198910000-00003.

A pilot controlled study of the use of imipramine to reduce myotonia

G G Gascon  1 , R D Staton, B D Patterson, P J Konewko, H Wilson, K M Carlson, R A Brumback
Affiliations
Clinical Trial

A pilot controlled study of the use of imipramine to reduce myotonia

G G Gascon et al. Am J Phys Med Rehabil. 1989 Oct.

Abstract

It has been hypothesized that myotonic dystrophy is caused by a generalized disorder of membrane aminergic and petidergic receptors. A single uncontrolled study has suggested that the affective symptomatology and muscular disability of this disorder might be improved by tricyclic antidepressant treatment. In the present study, 12 adult patients with myotonic dystrophy (age range 18-55 yr) were treated with imipramine and placebo in a double-blind crossover paradigm. Both grip and percussion myotonia were significantly improved by imipramine treatment independent of change in depressive symptomatology. Serum drug levels revealed nonlinear elimination kinetics for imipramine in this patient population.

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