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Comparative Study
. 2017 May 1;19(5):726-735.
doi: 10.1093/neuonc/now252.

Complete prevalence of malignant primary brain tumors registry data in the United States compared with other common cancers, 2010

Adah S Zhang  1   2 , Quinn T Ostrom  3   4 , Carol Kruchko  4 , Lisa Rogers  3   5 , David M Peereboom  3   6 , Jill S Barnholtz-Sloan  3   4
Affiliations
Comparative Study

Complete prevalence of malignant primary brain tumors registry data in the United States compared with other common cancers, 2010

Adah S Zhang et al. Neuro Oncol. .

Abstract

Background: Complete prevalence proportions illustrate the burden of disease in a population. This study estimates the 2010 complete prevalence of malignant primary brain tumors overall and by Central Brain Tumor Registry of the United States (CBTRUS) histology groups, and compares the brain tumor prevalence estimates to the complete prevalence of other common cancers as determined by the Surveillance, Epidemiology, and End Results Program (SEER) by age at prevalence (2010): children (0-14 y), adolescent and young adult (AYA) (15-39 y), and adult (40+ y).

Methods: Complete prevalence proportions were estimated using a novel regression method extended from the Completeness Index Method, which combines survival and incidence data from multiple sources. In this study, two datasets, CBTRUS and SEER, were used to calculate complete prevalence estimates of interest.

Results: Complete prevalence for malignant primary brain tumors was 47.59/100000 population (22.31, 48.49, and 57.75/100000 for child, AYA, and adult populations). The most prevalent cancers by age were childhood leukemia (36.65/100000), AYA melanoma of the skin (66.21/100000), and adult female breast (1949.00/100000). The most prevalent CBTRUS histologies in children and AYA were pilocytic astrocytoma (6.82/100000, 5.92/100000), and glioblastoma (12.76/100000) in adults.

Conclusions: The relative impact of malignant primary brain tumors is higher among children than any other age group; it emerges as the second most prevalent cancer among children. Complete prevalence estimates for primary malignant brain tumors fills a gap in overall cancer knowledge, which provides critical information toward public health and health care planning, including treatment, decision making, funding, and advocacy programs.

Keywords: brain tumors; epidemiology; glioblastoma; glioma; prevalence.

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Figures

Fig. 1
Fig. 1
The relative prevalence count proportions of SEER Cancer Statistics Review 1975–2010 common cancer sites and malignant primary brain and CNS tumors were stratified by age at prevalence groups. NOS, not otherwise specified.
Fig. 2
Fig. 2
Prevalence proportion per 100000 population of selected major CBTRUS histologies by age at prevalence groups.
See this image and copyright information in PMC

References

    1. Surveillance Epidemiology and End Results Program. Public Law 107–260 training.seer.cancer.gov/brain/non-malignant/history/public.html. Accessed November 14, 2016.
    1. Ostrom QT, Gittleman H, Liao P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. Neuro Oncol. 2014;16(s4):iv1–iv63. - PMC - PubMed
    1. Ostrom QT, Gittleman H, Fulop J, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2008–2012. Neuro Oncol. 2015;17(Suppl 4):iv1–iv62. - PMC - PubMed
    1. Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114(2):97–109. - PMC - PubMed
    1. Centers for Disease Control and Prevention. Data Collection of Primary Central Nervous System Numbers National Program of Cancer Registries Training Materials. Atlanta, Georgia: Department of Health and Human Services, Centers for Disease Control and Prevention;2004.

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