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. 2017 Mar;43(2):283-286.
doi: 10.1093/schbul/sbw178. Epub 2016 Dec 29.

The Search for Environmental Mechanisms Underlying the Expression of Psychosis: Introduction

Jim van Os  1   2 , Ulrich Reininghaus  1   3 , Andreas Meyer-Lindenberg  4
Affiliations

The Search for Environmental Mechanisms Underlying the Expression of Psychosis: Introduction

Jim van Os et al. Schizophr Bull. 2017 Mar.

Abstract

In this themed issue, a number of articles are presented that investigate environmental mechanisms in psychotic disorder. Below, we describe some of the challenges associated with this research, in terms of phenotypic definition, the nature of environmental impact and associated design and measurement issues.

Keywords: environment; mechanisms; psychosis.

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Figures

Fig. 1.
Fig. 1.
Phenotypic complexity of psychosis: overlapping dimensional domains of psychopathology with clinical and subclinical expression.
See this image and copyright information in PMC

References

    1. Perälä J, Suvisaari J, Saarni SI, et al. Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch Gen Psychiatry. 2007;64:19–28. - PubMed
    1. van Os J. “Schizophrenia” does not exist. BMJ. 2016;352:i375. - PubMed
    1. van Os J, Reininghaus U. Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry. 2016;15:118–124. - PMC - PubMed
    1. Button KS, Ioannidis JP, Mokrysz C, et al. Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci. 2013;14:365–376. - PubMed
    1. Macleod MR, Michie S, Roberts I, et al. Biomedical research: increasing value, reducing waste. Lancet. 2014;383:101–104. - PubMed