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. 2017 Jan 1:454:7-20.
doi: 10.1016/j.ica.2016.06.007. Epub 2016 Jun 18.

An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy

Jessica K White  1 , Russell H Schmehl  2 , Claudia Turro  1
Affiliations

An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy

Jessica K White et al. Inorganica Chim Acta. .

Abstract

This article is a short review that presents a short review of photosubstitution reactions of Ru(II) imine complexes and illustrates their use in the development of therapeutic agents. The review begins with an overview of the photophysical behavior and common photoreactions of Ru(II) imine complexes, with select examples from the literature since the 1960s. It is followed by a more detailed picture of the application of knowledge gained over the years in the development of Ru(II) complexes for photobiology and photodynamic therapy.

Keywords: Ruthenium photochemistry; imine complexes; photodynamic therapy; photosubstitution; temperature dependent luminescence.

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Figures

Figure 1
Figure 1
States diagram of typical Ru(II) imine complexes.
Figure 2
Figure 2
(A) Drawing of the bis-triazole complex and (B) structure of the monodentate intermediate species formed upon photolysis in CH3CN.
Figure 3
Figure 3
Postulated ligand to ligand charge transfer state intermediate associated with pyridine ligand loss in [Ru(cym)(bpy)(py-BODIPY)]2+ (S = solvent).
Figure 4
Figure 4
Structural representation Ru(II)-piano stool complexes that release a monodentate ligand, L, upon visible light irradiation and covalently bind to DNA.
Figure 5
Figure 5
Structural representations of complexes that covalently bind to DNA upon photodissociation of monodentate ligands.
Figure 6
Figure 6
A series of Ru(II) diimine complexes that undergo photoinduced bidentate ligand dissociation followed by covalent binding to DNA.
Figure 7
Figure 7
Structural representations of Ru(II) diimine complexes that release a bioactive molecule upon visible light irradiation.
Scheme 1
Scheme 1
Scheme 2
Scheme 2
See this image and copyright information in PMC

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